08:00am - 08:40am

NEUROENDOCRINE TUMOR I

Reviewer: João Evangelista (SP)
Moderator: Henry Najman (RJ)
International Panelists (live): Timothy Pawlik (USA) + Rene Adam
(FRA) + Olivier Soubrane (FRA) 
Panelist online: Rodrigo Vianna (USA)
Editor: Maria Ignez Braghiroli (SP)
Final Editor: Eduardo Ramos (PR)

Indicate the biopsy of the metastasis and/or the primary tumor?
When and which PET scan to order?
When to start with neoadjuvant treatment?
When not to start treatment with a somatostatin analogue and what is the best treatment sequence?
When to indicate octreotide, sunitinib, everolimus or lutetium?
How is the management in patients with Hereditary Syndromes like MEN-1, von Hippel-Lindau, and neurofibromatosis?

09:00am - 09:40am

NEUROENDOCRINE TUMOR II

Reviewer: Marcio Boff (RS) 
Moderator: Lucio Pacheco (RJ)
International Panelists (live): Timothy Pawlik (EUA) + Rene Adam
(FRA) + Olivier Soubrane (FRA) 
Panelist online: Lucas MacCormack (Argentina)
Editor: Wellington Andraus (SP)
Final Editor: Eduardo Ramos (PR)

When or not to resect the primary tumor?
Resectable primary lesion with unresectable metastases: Hepatectomy vs. Transplant.
Locoregional Therapy – Ablation and Embolization – When to indicate?
What is the role of incomplete resection?
Patients with invasion of vessels and adjacent organs with liver metastases;
Insulinoma of undetermined site

09:40am - 10:10am

Coffee Break

10:20am - 11:00am

NON-COLORECTAL AND NON-NEUROENDOCRINE LIVER METASTASES I (breast)

Reviewer: Fabio Luiz Waechter (RS) 
Moderator: Andre Godoy (SP)
International Panelists (live): Timothy Pawlik (EUA) + Rene Adam(FRA) + Olivier Soubrane (FRA) 
Panelist online: Karl Oldhafer (Germany)
Editor: Tercio Genzini (SP)
Final Editor: Ricardo Cotta (RJ)

What are the biological criteria used to indicate resection (HER-2, number of lesions, hormone receptors, response to chemotherapy)?
When to indicate ablation (radio ablation vs. Microwave)?
Is there any role in cytoreduction?
What is the role of chemo or radioembolization?
Has the indication for hepatectomy been increasing or decreasing?

11:20am - 12:00am

NON-COLORECTAL AND NON-NEUROENDOCRINE LIVER METASTASES II (Melanoma, Sarcoma, Renal)

Reviewer: Angelica Lucchese (RS) 
Moderator: Alessandro Diniz (SP)
International Panelists (live): Timothy Pawlik (EUA) + Rene Adam
(FRA) + Olivier Soubrane (FRA) 
Panelist online: Nicolas Jarufe (Chile)
Editor: Antonio Kalil (RS) 
Final Editor: Orlando Torres (MA)

When to indicate melanoma resection?
Does the primary site change management (ocular, unknown, skin)?
Presence of extrahepatic metastasis (pulmonary and bone);
Upfront resection vs. Neoadjuvant.
When to indicate hepatectomy for sarcoma?
When resecting metastases from renal tumors ?

12:20pm - 02:00pm

Lunch break

02:20pm - 03:00pm

NON-COLORECTAL AND NON-NEUROENDOCRINE LIVER METASTASES III (Pancreas – Periampullary)

Reviewer: Paulo Amaral (BA) 
Moderator: Carlos Eduardo R. Santos (RJ)
International Panelists (live): Timothy Pawlik (EUA) + Rene Adam (FRA) + Olivier Soubrane (FRA) Panelist online: Alejandro Serrablo (ESP)
Editor: Heber Salvador (SP) 
Final Editor: Ricardo Cotta (RJ)

Are there any indications for resection of liver metastases?
Synchronous vs. Mechronic;
Number of metastasis?
Peroperative diagnosis, whether to proceed with pancreatectomy?
Management of intestinal-type tumor metastases vs. biliopancreatic.

03:20pm - 04:00pm

SYNCHRONIC COLON METASTASIS

Reviewer: Raphael Araújo (SP) 
Moderator: Roberto Teixeira (SP)
International Panelists (live): Timothy Pawlik (EUA) + Rene Adam (FRA) + Olivier Soubrane (FRA) +
Panelist online: Aleksandar Karamarkovic (Serbia) + Hugo Marques (POR)
Editor: Marcelo Linhares (SP) 
Final Editor: Orlando Torres (MA)

Synchronous Diagnosis – when to indicate and not to indicate upfront resection?
What is the limit for simultaneous resections?
Does the number of liver metastases influence management?
When to indicate the PET SCAN?
How to carry out neojuvancy and how many cycles?
Conduct in metastases that disappear.

04:00pm - 04:30pm

Coffee break

04:40pm - 05:20pm

BILATERAL COLON METASTASIS – TECHNICAL ASPECTS

Reviewer: Eduardo Viana (BA)
Moderator: Marciano Anghinoni (PR)
International Panelists (live): Timothy Pawlik (EUA) + Rene Adam
(FRA) + Olivier Soubrane (FRA)
Panelist online: Guido Torzilli (ITA)
Editor: Flavio Silano (BA)
Final editor: Orlando Torres (MA) 

Two-stage hepatectomy vs. ALPPS;
ALPPS vs. hemi-ALPS;
What is the indication for minimally invasive surgery in multinodular liver?
Surgical resection vs. parenchyma preservation.
What to do with metastases that disappear?
What is the margin of safety?

05:40pm - 06:20pm

CLINICAL CASE

Lecturer: Maria Ignez Braghiroli (SP)
Reviewer: Marcela Crosara (SP)
International Panelists (live): Timothy Pawlik (EUA) + Rene Adam (FRA) + Olivier Soubrane (FRA) 
Panelist online: Alexandre Paladino (RJ)
Editor: Maria Ignez Braghroli(SP)
Final Editor: Eduardo Ramos (PR)

08:30pm - 11:30pm

Cocktail party and dinner

08:00am - 08:40am

LIVER METASTASES – SURGICAL TECHNIQUES TO INCREASE RESECTABILITY

Reviewer: Orlando Torres (MA) Flavio Silano (BA)
Moderator: Rinaldo Gonçalves (RJ)
International Panelists (live): Timothy Pawlik (EUA) + Rene Adam (FRA) + Olivier Soubrane (FRA) + Paulo Herman (BRA)
Panelist online: Eduardo de Santibanes (Argentina)
Editor: Marcelo Enne (RJ)
Final Editor: Ricardo Cotta (RJ)

Percutaneous portal embolization vs. conventional;
Embolization of segment IV;
Hepatic Deprivation;
Time for re-intervention;
Chemotherapy interval;
When to perform the “liver first”?

09:00 am - 09:40 am

RADIOEMBOLIZATION AND INTRA-ARTERIAL CHEMOTHERAPY

Reviewer: Rodrigo Gobbo (SP) Leonardo Galastri (SP)
Moderator: Marcio Boff (RS)
International Panelists (live): Timothy Pawlik (EUA) + Rene Adam (FRA) + Olivier Soubrane (FRA) + Paulo Herman (BRA)
Panelist online: Bruno Odisio (USA)
Editor: Leonardo Galastri (SP)
Final Editor: Orlando Torres (MA)

Indications;
Can venous thrombosis contraindicate the procedure or not?
Discuss hepatic and extrahepatic complications;
Can it be used as neoajuvancy?
When to indicate intra-arterial chemotherapy?

09:40 am - 10:10 am

Coffee Break

10:20 am - 11:00 am

DIAGNOSIS OF METACHRONOUS METASTASIS

Reviewer: Cassio Oliveira (PB) 
Moderator: Felipe Coimbra (SP)
International Panelists (live): Timothy Pawlik (USA) + Rene  Adam (FRA) + Olivier Soubrane (FRA) + Paulo Herman (BRA)
Panelist online: Alfred Kow (SIN)
Editor: Rodolpho Santana (BA)
Final editor: Ricardo Cotta (RJ)

When to indicate upfront surgery (time between diagnosis microsatellite instability, K-ras) ?
When does extrahepatic metastasis contraindicate resection?
Which lymph node groups may contraindicate resection?
What is the role of liver transplantation?

 11:20 am - 12:00 am

RECTAL CANCER METASTASIS

Reviewer: Rinaldo Danesi (SC)  
Moderator: Lucio Lucas (DF)
International Panelists (live): Timothy Pawlik (USA) + Rene  Adam (FRA) + Olivier Soubrane (FRA) + Paulo Herman (BRA)
Panelist online: Glenn Bonney (SIN)
Editor: Marco Aurelio (PR)
Final Editor: Orlando Torres (MA)

Is there an indication for upfront resection ?
What is the neoadjuvant treatment?
Complete response in the rectum – when to indicate liver resection?
Simultaneous resection vs. staged;
In unresectable lesions, when to operate the rectum?
Concomitant lung and liver metastasis

12:20 pm - 14:00 pm

Lunch Break

14:20 pm - 15:00 pm

TRANSECTION OF THE LIVER PARENCHYMA

Reviewer: Eduardo Ramos  (PR)  
Moderator: João Nicoluzzi (PR)
International Panelists (live): Timothy Pawlik (USA) + Rene  Adam (FRA) + Olivier Soubrane (FRA) + Paulo Herman (BRA)
Panelist online: Luca Aldrighetti
Editor: Michelli Fortunato (PR)
Final editor: Orlando Torres (MA)

What is my first option for liver transection?
How and how much can we use pringle?
When to carry out the previous approach? 
How often is Hanging Manouever and how do I do it?

15:20 pm - 16:00 pm

MINIMALLY INVASIVE SURGERY

Reviewer: Marcel Machado (SP) 
Moderator: Alexandre Resende (MG)
International Panelists (live): Timothy Pawlik (USA) + Rene  Adam (FRA) + Olivier Soubrane (FRA) + Paulo Herman (BRA)
Debater (online): Fabrizio  Di Benedetto (Italy)
Editor: Marcos Bellotto (SP)
Final Editor: Ricardo Cotta (RJ) 

When to indicate and not to indicate laparoscopic surgery vs. Robotics?
How to perform the minimally invasive pringle?
How do I perform laparoscopic and robotic transection?

Coffee break

16:40 pm - 17:20 pm

COMPLICATIONS AFTER HEPATECTOMY

Reviewer: Claudemiro Quireze (GO)
Moderator: Agnaldo Lima (MG)
International Panelists (live): Timothy Pawlik (USA) + Rene  Adam (FRA) + Olivier Soubrane (FRA) + Paulo Herman (BRA)
Panelist online: Martin Palavecino (Argentina) + Hugo Marques (POR)
Editor: Fabricio Coelho (SP)
Final editor: Eduardo Ramos (RJ)

Antibiotic Prophylaxis;
Acute portal vein thrombosis (reoperation vs. expectant);
Refractory ascites; biliary fistula > 300 ml/day early;
Biliary drain management;
Prevention of liver failure;
Preoperative guidelines.

17:40 pm - 18:20 pm

CLINICAL CASE

Lecturer: Eduardo Ramos (PR)
International Panelists (live): Timothy Pawlik (USA) + Rene  Adam (FRA) + Olivier Soubrane (FRA) + Paulo Herman (BRA)
Panelist online: Hugo Marques (POR)
Editor: Adriano Sampaio (SP)
Final editor: Ricardo Cotta (RJ) 

CONFERENCES (Recorded)
From oncologist to surgeon

Immunotherapy in colorectal metastasis for surgeons
Reviewer: Rodrigo Tancredi (PE)
Lecturer: Rodrigo Guedes  (BA)
Panelist Clinic: Paulo Hoff (SP)
Panelist Surgeon: Guilherme Cotti (SP)
Editor: Maria Ignez Braghroli(SP)
Final editor: Eduardo Ramos (PR)

Genetics in colorectal metastasis for surgeons
Reviewer: Marília Polo (SP)
Lecturer: Jorge Sabbaga (SP)
Panelist Clinic: Henry Najman (RJ)
Panelist Surgeon: Carlos David (SP)
Editor: Maria Ignez Braghroli (SP)

The importance of liquid  biopsy in surgical  patients
Reviewer: Lucila Rocha (DF)
Lecturer: Guilherme Stelko (PR)
Panelist Clinic: Jorge Sabbaga (SP)
Panelist Surgeon: Phillipe Abreu (EUA)
Editor: Maria Ignez Braghroli(SP)
Final editor: Eduardo Ramos (PR)